Concurrent classical and hypervirulent Klebsiella pneumoniae infection in distinct host niches revealed by a rapid nanopore whole-genome and plasmid sequencing method
We propose a plausible infection trajectory involving initial hypervirulent K. pneumoniae (hvKp) dissemination followed by niche-specific replacement by Classical K. pneumoniae (cKp) under antibiotic pressure. This case underscores that severe infections can arise from genetically "low-virulence" strains in certain host environments. Comprehensive genomic surveillance and aggressive clinical management strategies remain crucial for improving patient prognosis and understanding pathogen adaptation mechanisms within host niches.
Authors
- Dongling Wen
- Qiqi Wang (ORCID: https://orcid.org/0000-0003-2173-5404)
- Yuan Qing Qu
- Qiulei Zhong
- Huan Hu (ORCID: https://orcid.org/0000-0002-2976-0922)
- Yuyun Wang (ORCID: https://orcid.org/0009-0005-7101-704X)
- Lu Wang (ORCID: https://orcid.org/0000-0002-0073-0666)
- Yuan Liu (ORCID: https://orcid.org/0000-0003-2668-0350)
- Miao He (ORCID: https://orcid.org/0000-0003-4621-6846)
- Zizhen Tang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Chengdu Military General Hospital (CN)
- Chengdu Institute of Biology (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
- Genetic Technologies (Australia) (AU)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fcimb.2025.1633833
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Sichuan Province