PET imaging of mitochondrial complex-I in the adenine-induced tubulointerstitial nephropathy mouse model using [18F]BCPP-BF
Altogether, the findings suggest that [<sup>18</sup>F]BCPP-BF holds potential as an imaging biomarker for renal failure. However, further preclinical studies and validation in human subjects are necessary before it can be established as a reliable indicator for the progression of CKD.
Authors
- Tord Inghardt (ORCID: https://orcid.org/0000-0002-4804-9474)
- Hideo Tsukada
- Benjamin Challis (ORCID: https://orcid.org/0000-0002-1130-2851)
- Kenneth Dahl (ORCID: https://orcid.org/0000-0003-2948-2042)
- Maria Strömstedt (ORCID: https://orcid.org/0000-0001-8623-2088)
- Robert J. Unwin (ORCID: https://orcid.org/0000-0001-7839-6031)
- Hiroyuki Ohba
- Christer Halldin
- Miguel A. Cortés González (ORCID: https://orcid.org/0000-0003-4299-8860)
- Peter Johnström (ORCID: https://orcid.org/0009-0007-9725-9172)
- Zsolt Cselényi (ORCID: https://orcid.org/0000-0002-8479-6282)
- Magnus Schou (ORCID: https://orcid.org/0000-0002-4314-2418)
- Miklós Tóth (ORCID: https://orcid.org/0000-0002-1652-7136)
- Aurelija Jučaitė (ORCID: https://orcid.org/0000-0002-2281-6436)
- Vasco C. Sousa (ORCID: https://orcid.org/0000-0002-0086-6168)
- Charles D. Ericsson
- Anna Reznichenko
Institutions
- Semmelweis University (HU)
- Hamamatsu Photonics (Japan) (JP)
- Stockholm County Council (SE)
- Karolinska Institutet (SE)
- AstraZeneca (Brazil) (BR)
- AstraZeneca (Japan) (JP)
- AstraZeneca (Finland) (FI)
- AstraZeneca (Sweden) (SE)
- AstraZeneca (Germany) (DE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s41181-025-00392-1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Karolinska Institutet