Genomic characterisation of recurrent Mycobacterium avium isolates from chronically infected patients reveals patterns of within-host evolution
Whole genome sequencing provides novel insights into within-host evolution of M. avium and highlights potentially important mycobacterial strategies to enhance persistence that may provide new targets for therapeutic investigation.
Authors
- Frederick J. Sheedy (ORCID: https://orcid.org/0000-0003-2645-8493)
- Sharee A. Basdeo (ORCID: https://orcid.org/0000-0001-5616-6665)
- Emma Roycroft (ORCID: https://orcid.org/0009-0003-2969-8668)
- Aaron M. Walsh (ORCID: https://orcid.org/0000-0001-7058-728X)
- Laura E. Gleeson (ORCID: https://orcid.org/0000-0001-7536-3867)
- Paul D. Cotter (ORCID: https://orcid.org/0000-0002-5465-9068)
- Margaret Fitzgibbon (ORCID: https://orcid.org/0000-0001-8822-214X)
- Fiona Crispie (ORCID: https://orcid.org/0000-0002-3590-673X)
- Anne-Marie McLaughlin (ORCID: https://orcid.org/0000-0001-9861-9714)
- Joseph Keane (ORCID: https://orcid.org/0000-0001-5313-385X)
- Kate Hinchion
Institutions
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Trinity College Dublin (IE)
- University College Cork (IE)
- St. Patrick's Hospital (IE)
- APC Microbiome Institute (IE)
- St. James's Hospital (IE)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s13073-025-01549-y
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Service Executive
- Irish Research Council