L-Proline supplementation preserves sperm function and chromatin integrity in asthenozoospermic patients during cryopreservation
The results suggest that adding 2 mM L-proline into the freezing medium effectively protects human sperm quality and chromatin integrity in asthenozoospermic samples by mitigating cryopreservation-induced nitro-oxidative stress. This strategy holds promise for improving assisted reproductive technology (ART) outcomes in men with asthenozoospermia.
Authors
- Amir Hossein Hashemian (ORCID: https://orcid.org/0000-0003-4742-6466)
- Masoumeh Golestan Jahromi (ORCID: https://orcid.org/0000-0001-8402-8577)
- Mojtaba Moradi (ORCID: https://orcid.org/0000-0002-9859-5705)
- Azita Faramarzi
- Elham Ghanbari (ORCID: https://orcid.org/0000-0001-6040-1912)
Institutions
- Kermanshah University of Medical Sciences (IR)
- Jahrom University of Medical Sciences (IR)
Publication Details
- Journal
- Basic and Clinical Andrology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s12610-025-00286-x
- Citations
- 1
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Kermanshah University of Medical Sciences