PROTECTIVE AND THERAPEUTIC EFFECTS OF OLEIC ACID IN EXPERIMENTAL MYOGLOBİNURIC ACUTE RENAL FAILURE MODEL

OBJECTIVE: This study aims to investigate the potential protective and therapeutic effects of oleic acid recognized for its antioxidant and anti-inflammatory properties on acute renal failure (ARF) in an experimental model. MATERIAL AND METHODS: In this study, 24 Wistar Albino female rats were randomly divided into 3 groups of 8 each. Group 1 was used as the control group. Group 2 was given 50% hypertonic glycerol (8 ml/kg, i.m.) to induce renal injury. Group 3, glycerol plus oleic acid (10 mg/kg, intragastrically) respectively. Renal injury was assessed by measuring serum urea and creatinine. Biochemical markers malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), total thiol, catalase (CAT), paraoxanase (PON) values were measured to evaluate the balance between oxidative stress and antioxidant defense systems. RESULTS: Glycerol administration caused a significant increase in serum creatinine and urea levels, indicating acute renal dysfunction. Oleic acid treatment provided partial improvement in these parameters indicating renal function. When we look at biochemical parameters, MDA, TOS and OSI levels reflecting oxidative stress were significantly increased in glycerol-administered rats, while TAS, total thiol, CAT and PON levels were significantly decreased. Oleic supplementation significantly reversed these changes, showing antioxidant and nephroprotective effects. CONCLUSIONS: The results obtained provide new insights into the potential nephroprotective effects of oleic acid on the kidney and clearly demonstrate the need for further studies to elucidate the mechanisms underlying this effect and to evaluate its clinical applicability.