Three-Component Cycloaddition Reaction of Aryne, Acrylate, and Imine Derivatives: Divergent Synthesis of Hexahydropyrrolo[1,2- <i>a</i> ]quinolines and 1,4-Dihydroquinolines
A novel synthetic strategy toward hexahydropyrrolo[1,2-<i>a</i>]quinolines and 1,4-dihydroquinolines has been demonstrated, involving aryne-enabled three-component reactions with acrylate and imine derivatives. This transition-metal-free three-component cycloaddition reaction is scalable and operates with good functional group compatibility. The proposed reaction pathway is supported by a deuterium-labeling experiment.
Authors
- Chuanjun Song (ORCID: https://orcid.org/0000-0001-7733-578X)
- Xin Wang (ORCID: https://orcid.org/0000-0002-0333-0238)
- Yanyan Zhu (ORCID: https://orcid.org/0000-0001-6005-8421)
- Wenbo Cai
Institutions
- Zhengzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1021/acs.orglett.5c03900
- Primary Topic
- Cyclization and Aryne Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00