Sophora tonkinensis enhances activation of cGAS-STING pathway and restrains HBV replication
STE could effectively promote the activation of cGAS-STING pathway by facilitating cGAMP synthesis by cGAS, exhibiting obviously inhibitory effect on HBV replication. STE might serve as an effective therapeutic approach against viral infections diseases.
Authors
- Yuanyuan Guo (ORCID: https://orcid.org/0000-0002-5122-8545)
- Jincai Wen
- Ang Huang (ORCID: https://orcid.org/0000-0001-8876-9903)
- Yingjie Xu (ORCID: https://orcid.org/0000-0001-6966-6247)
- Xueting Wang (ORCID: https://orcid.org/0000-0002-0524-8545)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Siqi Huang (ORCID: https://orcid.org/0000-0002-4813-5073)
- Xianling Wang (ORCID: https://orcid.org/0000-0001-7350-4101)
- Zongliang Lu
- Xiaoyan Zhan (ORCID: https://orcid.org/0000-0002-2446-5967)
- Zhaofang Bai
- Junling Cao
- Zhijie Ma
Institutions
- Beijing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- China National Chemical Engineering (China) (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
- Beijing Ditan Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fphar.2025.1630460
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Beijing Nova Program
- National Key Research and Development Program of China