Metabolic-immune crosstalk in myocardial infarction: RLF and SMCHD1 identified as causal therapeutic targets via integrated lactylation-MR analysis
This study pioneers the integration of lactylation modification with MR analysis for MI, establishing RLF and SMCHD1 as causal diagnostic biomarkers. Their dual roles in promoting metabolic dysregulation and pro-inflammatory immune infiltration position them as promising therapeutic targets for MI intervention.
Authors
- Lingyan Yuan
- Jingyuan Tang (ORCID: https://orcid.org/0000-0002-9720-3060)
- Yongli Han (ORCID: https://orcid.org/0000-0001-9673-9181)
Institutions
- Shanghai Normal University (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fcell.2025.1653551
- Citations
- 1
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.80