Corticosteroids with low glucocorticoid activity as a potential therapeutic strategy for post‐COVID‐19 myalgic encephalomyelitis/chronic fatigue syndrome in patients with bipolar affective disorder: A case report
The clinical course suggests that GR-dominant corticosteroids may exacerbate psychiatric instability in patients with mood disorders. Simultaneously, MR-favoring agents, such as hydrocortisone, may offer a safer therapeutic alternative for managing HPA axis dysfunction. This case underscores the critical role of receptor selectivity in corticosteroid therapy, particularly in patients with comorbid psychiatric conditions, and highlights the necessity for individualized treatment strategies that integrate both endocrine and neuropsychiatric considerations.
Authors
- Teppei Akimoto (ORCID: https://orcid.org/0000-0002-7472-5210)
- Kazuo Kasahara (ORCID: https://orcid.org/0000-0001-5551-1543)
- Jin Narumoto (ORCID: https://orcid.org/0000-0002-8262-3177)
- Haruki Ikawa (ORCID: https://orcid.org/0000-0003-3829-0472)
- Riki Kitaoka
- Kohei Nakajima (ORCID: https://orcid.org/0000-0001-5589-4054)
- Teruyuki Matsuoka (ORCID: https://orcid.org/0000-0001-7683-7825)
- Nobutaka Ayani (ORCID: https://orcid.org/0000-0003-1130-052X)
- Yoshiyuki Nakajima
Institutions
- Kyoto Prefectural University of Medicine (JP)
- National Institute of Technology, Maizuru College (JP)
- Maizuru Municipal Hospital (JP)
- Kyoto University Hospital (JP)
- Municipal Hirakata City Hospital (JP)
Publication Details
- Journal
- Psychiatry and Clinical Neurosciences Reports
- Published
- 2025-10-12
- DOI
- https://doi.org/10.1002/pcn5.70222
- Citations
- 1
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 1.11