Metabolic resilience governs sex-specific pain recovery during hormonal aging: a multi-omics study of neuropathy in mice
These patterns highlight a non-linear, sex-specific interaction between biological aging and injury response, where hormonal decline reprograms the metabolic trajectory and reshapes pain outcomes. Metabolic resilience governs sex-specific recovery following nerve injury by directing early systemic adaptations that precede and predict long-term pain trajectories. These results define mechanistically anchored, sex- and age-specific biomarkers, and propose preclinical targets for timely, personalized interventions in age-associated neuropathic pain.
Authors
- Chiara Parisi (ORCID: https://orcid.org/0000-0003-1350-3929)
- Cláudia Rossi (ORCID: https://orcid.org/0000-0003-0949-0280)
- Domenico Ciavardelli (ORCID: https://orcid.org/0000-0002-1087-847X)
- Roberto Coccurello (ORCID: https://orcid.org/0000-0001-7059-7015)
- Valentina Vacca (ORCID: https://orcid.org/0000-0003-2657-0450)
- Federica De Angelis (ORCID: https://orcid.org/0000-0001-5773-3414)
- Valentina Mastrorilli (ORCID: https://orcid.org/0000-0002-2527-7618)
- Sara Marinelli (ORCID: https://orcid.org/0000-0001-5393-4796)
- Giacomo Giacovazzo (ORCID: https://orcid.org/0000-0001-7430-2835)
- Luisa Pieroni (ORCID: https://orcid.org/0000-0001-7141-1817)
- Ilaria Cicalini (ORCID: https://orcid.org/0000-0002-9792-2225)
- Zuleyha Nihan Yurtsever
Institutions
- University of Teramo (IT)
- Università degli Studi di Enna Kore (IT)
- University of Chieti-Pescara (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- IRCCS San Camillo Hospital (IT)
- European Brain Research Institute (IT)
- Institute for Complex Systems (IT)
- Fondazione Santa Lucia (IT)
- Institute of Cell Biology and Neurobiology (IT)
Publication Details
- Journal
- Frontiers in Pain Research
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fpain.2025.1655712
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00