Evaluating the risk of osteopenia-related adverse events with antiepileptic drugs: a pharmacovigilance study based on the FAERS database
Previous studies have only identified a link between phenytoin and osteopenia, while the relationship between valproic acid and this adverse event remains controversial, and gabapentin and eslicarbazepine have not been systematically reported. The findings provide the first evidence of an association between these four antiepileptic drugs and osteopenia, offering insights and guidance for clinical recognition and prevention of such events.
Authors
- Xiang Y. Han (ORCID: https://orcid.org/0000-0001-8472-0870)
- Yue Zhou (ORCID: https://orcid.org/0000-0003-0246-3140)
- Hongning Hua (ORCID: https://orcid.org/0000-0001-5102-6479)
- Yumeng Wang (ORCID: https://orcid.org/0000-0002-2282-0814)
- Haoyu Feng
- Nan Yang (ORCID: https://orcid.org/0000-0003-4237-4513)
- Yulin Chen (ORCID: https://orcid.org/0000-0002-4262-1337)
Institutions
- Shanxi Medical University (CN)
- Xinqiao Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fphar.2025.1685289
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00