The chemokines CCL22 and CCL17 are a defining feature of type 2 stimulated human lung macrophages and exhibit different metabolic dependencies
These data clarify hallmarks of human lung macrophage activation and polarisation in addition to revealing novel metabolic regulation of type 2 markers.
Authors
- Peter C. Cook (ORCID: https://orcid.org/0000-0002-5208-4985)
- Angela Simpson (ORCID: https://orcid.org/0000-0003-2733-6666)
- Amanda J. L. Ridley (ORCID: https://orcid.org/0000-0001-7626-481X)
- Douglas Philip Dyer (ORCID: https://orcid.org/0000-0001-5567-6241)
- Maria Feeney
- Annabel J. Curle (ORCID: https://orcid.org/0000-0002-9105-1131)
- Jane Hughes (ORCID: https://orcid.org/0000-0003-1389-3402)
- Lee M. Booty (ORCID: https://orcid.org/0000-0003-3003-5872)
- Stefano A. P. Colombo (ORCID: https://orcid.org/0000-0002-3346-3437)
- Andrew S. MacDonald
Institutions
- GlaxoSmithKline (United Kingdom) (GB)
- Walter and Eliza Hall Institute of Medical Research (AU)
- University of Exeter (GB)
- Manchester Academic Health Science Centre (GB)
- Age UK (GB)
- Wellcome Centre for Cell-Matrix Research (GB)
- Centre for Immunity, Infection and Evolution (GB)
- Medical Research Council (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1654717
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Exeter
- Medical Research Council Centre for Medical Mycology
- Medical Research Council