Fibroblast heterogeneity and FN1-mediated signaling in endometriosis revealed by single-cell and spatial transcriptomics
This study revealed the transcriptional and spatial heterogeneity of Fibroblast in EM syndrome, and identified the C2 <i>CXCR4</i> <sup>+</sup> Fibroblast subpopulation as a may represent key driver of fibrosis and immune regulation. Our integrated omics approach provided new mechanistic insights into the pathogenesis of EM and pointed out new targets for therapeutic intervention.
Authors
- Zhikai Xiahou
- Hongmei Ju
- Sheng Fang (ORCID: https://orcid.org/0009-0002-1078-2184)
- Chunyan Li (ORCID: https://orcid.org/0000-0003-3014-3363)
- Rugen Yan (ORCID: https://orcid.org/0009-0002-3046-5688)
- Wenwen Shao (ORCID: https://orcid.org/0009-0002-8888-3225)
- Yuan Xu
- Pingping Cai (ORCID: https://orcid.org/0009-0002-1517-5236)
Institutions
- Kunming University of Science and Technology (CN)
- Nanjing University of Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Kunming Medical University (CN)
- Shandong Provincial Hospital (CN)
- China Institute of Sport Science (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Shandong First Medical University (CN)
- Beijing Sport University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1680849
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00