Effects of drospirenone and ethinylestradiol tablets (II) combined with metformin on the composition of gut microbiota in polycystic ovary syndrome with insulin resistance

1. There is a difference in the relative abundance of <i>Acidimicrobiia</i> in the gut between PCOS-NIR and PCOS-IR patients before treatment, which is positively correlated with HOMA-IR, suggesting that <i>Acidimicrobiia</i> may be involved in the occurrence of PCOS-IR. 2. Drospirenone and ethinylestradiol tablets (II) combined with metformin tablets can change the gut microbiota relative abundance of patients with PCOS-IR, which may be related to the improvement of host lipid and glucose metabolism.