Sex/gender differences in lifetime dementia risk among Asian American and White older adults

Evidence on differences in dementia risk by sex and gender is mixed. We aimed to compare lifetime dementia risk by sex/gender among Asian American and non-Latino White adults aged 60 and older. We included Chinese (<i>n</i> = 6415), Filipino (<i>n</i> = 5020), Japanese (<i>n</i> = 3314), South Asian (<i>n</i> = 1061), and non-Latino White (<i>n</i> = 143,667) Kaiser Permanente Northern California members aged ≥60 years who completed health surveys (2002-2020) and were dementia-free at baseline. We estimated cause-specific cumulative dementia incidence from age 60 to 95 years (i.e., lifetime dementia risk, treating death as a competing event) and evaluated sex/gender differences. Lifetime dementia risk was higher among women in all groups, ranging from 7 (95% CI: 2-13) percentage points higher for Japanese women vs. men to 21 (8-38) percentage points higher for South Asian women vs. men. Variations of sex/gender differences across racial and ethnic groups are potentially driven by dementia-free mortality and social and structural factors.

Authors

Institutions

Publication Details

Journal
npj Dementia
Published
2025-10-13
DOI
https://doi.org/10.1038/s44400-025-00038-8
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Sex/gender differences in lifetime dementia risk among Asian American and White older adults

Elizabeth Rose Mayeda, Alka M. Kanaya, Yingyan Wu, Eleanor Hayes‐Larson et al.
npj Dementia
Dementia and Cognitive Impairment Research
article

Sex/gender differences in lifetime dementia risk among Asian American and White older adults

Elizabeth Rose Mayeda, Alka M. Kanaya, Yingyan Wu, Eleanor Hayes‐Larson, Gilbert C. Gee, Ron Brookmeyer, Alexander Ivan B. Posis, Paola Gilsanz, Yixuan Zhou, Holly Elser, Rachel A. Whitmer, L. Paloma Rojas-Saunero
article en

Abstract

Evidence on differences in dementia risk by sex and gender is mixed. We aimed to compare lifetime dementia risk by sex/gender among Asian American and non-Latino White adults aged 60 and older. We included Chinese (<i>n</i> = 6415), Filipino (<i>n</i> = 5020), Japanese (<i>n</i> = 3314), South Asian (<i>n</i> = 1061), and non-Latino White (<i>n</i> = 143,667) Kaiser Permanente Northern California members aged ≥60 years who completed health surveys (2002-2020) and were dementia-free at baseline. We estimated cause-specific cumulative dementia incidence from age 60 to 95 years (i.e., lifetime dementia risk, treating death as a competing event) and evaluated sex/gender differences. Lifetime dementia risk was higher among women in all groups, ranging from 7 (95% CI: 2-13) percentage points higher for Japanese women vs. men to 21 (8-38) percentage points higher for South Asian women vs. men. Variations of sex/gender differences across racial and ethnic groups are potentially driven by dementia-free mortality and social and structural factors.

npj DementiaVol. 1(1)
University of Southern California (US), San Francisco General Hospital (US), Kaiser Permanente (US), University of California, Los Angeles (US), University of California, San Francisco (US), University of Pennsylvania (US), University of California, Davis (US)
Ellison Medical Foundation, Wayne and Gladys Valley Foundation, Kaiser Permanente, National Institute on Aging
Openalex Percentile: Top 65%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.