Role of intercellular interactions on single cell and population level responses: considerations for multicellular bioreporter design

The results show significant differences between the results of multicellular and single cellular simulations, which demonstrates the importance of simulating multiple cells to obtain nuanced results. The amplification of signal protein produced by an increasing number of simulated bioreporter cells indicates great potential for multicellular bioreporter designs to amplify response magnitude and sensitivity on the individual cellular level. These results warrant further research into the application of different simulation algorithms and multicellular bioreporter design and modeling.