Overexpression of Scr1 protein induces strong changes in the transcriptome and metabolome of Streptomyces coelicolor that affect antibiotic production
The overexpression of Scr1 in S. coelicolor causes changes in the regulation of secondary metabolite biosynthesis that may be related to the alteration of several other important primary metabolites. This transcriptional and metabolomic analysis takes a step forward in elucidating the pleiotropic role of the Scr1 protein in developmental processes and its importance in the biosynthesis of secondary metabolites in S. coelicolor. A model of its regulatory network is presented.
Authors
- Margarita Díaz (ORCID: https://orcid.org/0000-0003-4286-1506)
- Carolina Riascos (ORCID: https://orcid.org/0000-0002-1824-3567)
- Gemma Fernández-García (ORCID: https://orcid.org/0000-0002-3472-2840)
- Ramón I. Santamaría (ORCID: https://orcid.org/0000-0002-2181-6776)
- Ángel Manteca (ORCID: https://orcid.org/0000-0001-8001-8988)
- Javier García-Martín
Institutions
- Universidad de Oviedo (ES)
- Instituto de Biología Funcional y Genómica (ES)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s12934-025-02843-5
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Estatal de Investigación