Oral morphine pharmacokinetics in healthy children and the effect of genetic polymorphisms: An exploratory study
Oral morphine's active metabolites have a longer t<sub>1/2</sub> and an <i>OPMR1</i> SNP rs563649 may underlie variability in efficacy and safety. Clinical Trials Registration: clinicaltrials.gov NCT01690780.
Authors
- Naveen Poonai (ORCID: https://orcid.org/0000-0003-1540-0413)
- Nicholas C. Tonial (ORCID: https://orcid.org/0000-0002-4398-245X)
- Samina Ali (ORCID: https://orcid.org/0000-0002-0595-364X)
- Jaime Reardon
- Colin J.D. Ross (ORCID: https://orcid.org/0000-0003-1476-7037)
- Abdelbaset Elzagallaai (ORCID: https://orcid.org/0000-0001-8750-6028)
- Natasha Leporé (ORCID: https://orcid.org/0000-0002-8379-674X)
- Bradley L. Urquhart (ORCID: https://orcid.org/0000-0001-8324-1472)
- Lauren Faught
- Michael J. Rieder
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- University of British Columbia (CA)
- Children’s Health Research Institute (CA)
- Stollery Children's Hospital (CA)
Publication Details
- Journal
- Paediatrics & Child Health
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1093/pch/pxaf084
- Primary Topic
- Pediatric Pain Management Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00