DB-OTO Gene Therapy for Inherited Deafness

DB-OTO gene therapy improved hearing in patients with <i>OTOF</i>-related deafness, enabling natural acoustic hearing and normalizing hearing sensitivity in 3 of 12 treated patients. (Funded by Regeneron Pharmaceuticals; ClinicalTrials.gov number, NCT05788536.).

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Institutions

Publication Details

Journal
New England Journal of Medicine
Published
2025-10-12
DOI
https://doi.org/10.1056/nejmoa2400521
Citations
19
Primary Topic
Hearing, Cochlea, Tinnitus, Genetics
Type
article
Field-Weighted Citation Impact
27.83
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article

DB-OTO Gene Therapy for Inherited Deafness

Robert Nash, G. S. Wilson, Aiden Eliot Shearer, Tera Quigley et al.
19 citations
New England Journal of Medicine
Hearing, Cochlea, Tinnitus, Genetics
27.83
article

DB-OTO Gene Therapy for Inherited Deafness

Robert Nash, G. S. Wilson, Aiden Eliot Shearer, Tera Quigley, Jonathon P. Whitton, William J. Riggs, Jay T. Rubinstein, Lawrence R. Lustig, Aris Baras, Manohar Bance, Akira Ishiyama, Meghan C. Drummond, Vassili Valayannopoulos, Hazem E. Hassan, C. Eduardo Corrales, Bret J. Musser, Leah R. Sabin, Christos A. Kyratsous, Ignacio del Castillo, Manuel Manrique, Evie C. Landry, Hubert Löwenheim, Cedric V. Pritchett, Rubén Polo, Gary Herman, George D. Yancopoulos, John H. Greinwald, Daniela Carvalho, Rong Liu, Yanping Chen, Christian Weber, Steven Harvey, Jeffery J. Anderson, Susan C. Irvin
article en
19 citations

Abstract

DB-OTO gene therapy improved hearing in patients with <i>OTOF</i>-related deafness, enabling natural acoustic hearing and normalizing hearing sensitivity in 3 of 12 treated patients. (Funded by Regeneron Pharmaceuticals; ClinicalTrials.gov number, NCT05788536.).

New England Journal of MedicineVol. 394(11)
Brigham and Women's Hospital (US), Cincinnati Children's Hospital Medical Center (US), Boston Children's Hospital (US), NewYork–Presbyterian Hospital (US), Harvard University (US), Regeneron (United States) (US), Medical College of Wisconsin (US), Instituto Cajal (ES), University of Cambridge (GB), Columbia University Irving Medical Center (US), University of California San Diego (US), NanoAffix Science (United States) (US), Nemours Children's Health System (US), Seattle Children's Hospital (US), Centro de Investigación Biomédica en Red (ES), Instituto Ramón y Cajal de Investigación Sanitaria (ES), Clinica Universidad de Navarra (ES), Institute of Child Health (IN), Nemours Children's Clinic (US), University College London (GB), University of Cincinnati (US), University of Tübingen (DE), Universidad de Navarra (ES)
Openalex Percentile: Top 0%
Hearing, Cochlea, Tinnitus, Genetics
27.83
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