Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trial
Despite reduction in dp-ucMGP, high-dose vitamin K2 and D3 supplementation did not affect EAT, PCAT or systemic inflammation over 24 months. Alternative strategies may be needed to target inflammatory pathways in cardiovascular disease prevention.
Authors
- Lars Melholt Rasmussen (ORCID: https://orcid.org/0000-0001-5795-4794)
- Anna Mejldal (ORCID: https://orcid.org/0000-0002-4612-4338)
- Niels Erik Frandsen (ORCID: https://orcid.org/0000-0003-4584-6723)
- Axel Cosmus Pyndt Diederichsen (ORCID: https://orcid.org/0000-0002-1285-4826)
- Susanne Hosbond (ORCID: https://orcid.org/0000-0003-2653-2665)
- Gražina Urbonavičienė (ORCID: https://orcid.org/0000-0002-9323-7503)
- Jes S. Lindholt (ORCID: https://orcid.org/0000-0001-9536-4488)
- Damini Dey (ORCID: https://orcid.org/0000-0003-2236-6970)
- Selma Hasific (ORCID: https://orcid.org/0000-0001-7654-8492)
- Kristian Altern Øvrehus (ORCID: https://orcid.org/0000-0003-2454-5446)
- Søren Auscher (ORCID: https://orcid.org/0000-0003-0399-2503)
- Sören L. Becker (ORCID: https://orcid.org/0000-0003-3634-8802)
- Jess Lambrechtsen (ORCID: https://orcid.org/0000-0002-9976-9981)
- Emil Johannes Ravn (ORCID: https://orcid.org/0000-0002-8992-5493)
- Dilek Hunerel Alan
Institutions
- Cedars-Sinai Medical Center (US)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Open Data Institute (GB)
- Lillebaelt Hospital (DK)
- Svendborg Sygehus (DK)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-10-12
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120540
- Citations
- 1
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 1.39