Distinct trajectories of humoral immune responses after SARS-CoV-2 mRNA vaccination in autoimmune inflammatory rheumatic diseases: A group-based trajectory analysis
We identified distinct antibody response trajectories in patients with AIRDs, including a subgroup with persistently low humoral immune responses despite repeated vaccinations. This study highlights the need for personalised vaccination strategies that consider individual clinical and immunological factors to optimise protection in this vulnerable populations.
Authors
- Sumiyuki Nishida
- Teruaki Murakami
- Shoichiro Inokuchi (ORCID: https://orcid.org/0000-0002-5501-8852)
- Kohei Tsujimoto (ORCID: https://orcid.org/0000-0001-6958-2983)
- Atsushi Kumanogoh (ORCID: https://orcid.org/0000-0003-4749-7117)
- Shinichiro Nameki (ORCID: https://orcid.org/0000-0003-3716-4554)
- Yasutaka Okita (ORCID: https://orcid.org/0000-0003-3620-8412)
- Masayuki Nishide (ORCID: https://orcid.org/0000-0001-6060-1228)
- Masashi Narazaki (ORCID: https://orcid.org/0000-0002-5613-4409)
- Yuko Yoshimine (ORCID: https://orcid.org/0000-0001-9182-7473)
- Jun Fujimoto
- Kiyowo Kosaka
- Saori Amiya
- Takayoshi Morita (ORCID: https://orcid.org/0000-0002-7111-9506)
- Yuta Yamaguchi (ORCID: https://orcid.org/0000-0002-8314-9294)
- Yasuhiro Kato (ORCID: https://orcid.org/0000-0002-4050-2350)
- Takahiro Kawasaki (ORCID: https://orcid.org/0000-0002-8625-7899)
- Sayaka Nagao
Institutions
- The University of Osaka (JP)
Publication Details
- Journal
- Vaccine
- Published
- 2025-10-12
- DOI
- https://doi.org/10.1016/j.vaccine.2025.127771
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00