Cover Feature: Photoactivated Anticancer Activity of Cobalt(III) Complexes with Naturally Occurring Flavonoids Chrysin and Silibinin (ChemBioChem 20/2024)
The article 10.1002/cbic.202400484 by Samya Banerjee, Tukki Sarkar, Akhtar Hussain, and co-workers highlights the synthesis, characterization, and evaluation of six new mixed-ligand cobalt(III) complexes for photodynamic therapy (PDT) in cancer treatment. Notably, complexes Co5 and Co6, featuring dipyridophenazine and the naturally occurring flavonoids chrysin and silibinin, exhibit significant toxicity against cervical and lung cancer cells under visible light with low micromolar IC50 values, while showing minimal toxicity in the absence of light. These complexes induce apoptosis via singlet oxygen generation following a type-II PDT pathway, displaying remarkable selectivity and biocompatibility for potential cancer PDT applications.
Authors
- Ashish Yadav (ORCID: https://orcid.org/0000-0001-5452-377X)
- Samya Banerjee (ORCID: https://orcid.org/0000-0003-4393-4447)
- Akhtar Hussain (ORCID: https://orcid.org/0000-0001-6742-3321)
- Tukki Sarkar (ORCID: https://orcid.org/0000-0002-7852-4344)
- Aarti Upadhyay (ORCID: https://orcid.org/0000-0001-9638-1191)
- Arpan Bera (ORCID: https://orcid.org/0000-0001-8271-5285)
- Jyotirmoy Dutta
Institutions
- National Law University and Judicial Academy (IN)
- Indian Institute of Chemical Technology (IN)
- Indian Institute of Technology BHU (IN)
- Indian Institute of Science Bangalore (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- ChemBioChem
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1002/cbic.202482002
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00