The use of tNGS in the diagnosis of Q fever: A case report and review of cases of liver injury

This report describes a case of Q fever with predominantly liver injury presentation. We used targeted next generation sequencing (tNGS) and immunologic methods to identify a case of acute stage infection of Q fever with liver injury; prompt diagnosis and treatment significantly improved the patient's prognosis and life quality. Further, to predict the homology and genetic diversity, the patient's sample was partially sequenced for insertion sequence (IS)<i>1111</i> gene. Additionally, we reviewed similar cases in the past five years, aiming to provide evidence-based evidence for subsequent accurate diagnosis and treatment.