Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
These results highlight the pivotal role of midbrain damage for the amplification of neuroinflammatory cascades and AD pathology. Moreover, they offer mechanistic insight into the faster progression to dementia in patients with midbrain deficits. By translating these findings into clinical practice, we can advance towards a precision medicine approach in disease management.
Authors
- Giovanna Borsellino (ORCID: https://orcid.org/0000-0002-4227-6481)
- Marcello D’Amelio (ORCID: https://orcid.org/0000-0001-6526-1832)
- Annalisa Nobili (ORCID: https://orcid.org/0000-0001-8369-1561)
- Flavio Keller (ORCID: https://orcid.org/0000-0002-6449-6960)
- Paraskevi Krashia (ORCID: https://orcid.org/0000-0002-8476-9233)
- Martina Montanari (ORCID: https://orcid.org/0000-0002-6424-9716)
- Ramona Marino
- Stefano Puglisi‐Allegra (ORCID: https://orcid.org/0000-0002-9433-2000)
- Luana Saba
- Elena Spoleti (ORCID: https://orcid.org/0000-0002-6555-785X)
- Emanuele Claudio Latagliata (ORCID: https://orcid.org/0000-0001-8402-2757)
- Emma Cauzzi (ORCID: https://orcid.org/0000-0003-0236-5276)
- Livia La Barbera (ORCID: https://orcid.org/0000-0003-4556-4451)
- Marco De Bardi (ORCID: https://orcid.org/0000-0001-8217-970X)
- Gilda Loffredo
- Claudia Palazzo (ORCID: https://orcid.org/0000-0003-1450-7171)
- Luisa Lo Iacono (ORCID: https://orcid.org/0000-0003-2979-6957)
- Maria Teresa Viscomi (ORCID: https://orcid.org/0000-0002-9096-4967)
- Serena Ficchì
- Claudio Zaccone
- Maria Luisa De Paolis
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Università Campus Bio-Medico (IT)
- Istituto Neurologico Mediterraneo (IT)
- Fondazione Santa Lucia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-10-12
- DOI
- https://doi.org/10.1186/s13024-025-00893-2
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05