Dual Primary Gastric Adenocarcinoma and Diffuse Large B-Cell Lymphoma: A Unique Case With a Cascade of Rare Complications

Concurrent presentation of two primary gastrointestinal cancers is extremely rare. We describe an unusual presentation of a 69-year-old patient without a significant past medical history, who was diagnosed simultaneously with diffuse large B-cell lymphoma and gastric adenocarcinoma. This case is distinguished by the development of severe, rarely reported complications such as duodenocolonic fistula, bowel perforation, pulmonary embolism, and multi-organ failure. The combination of those complications underscores the exceptional complexity of management.

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Publication Details

Journal
Cureus
Published
2025-10-12
DOI
https://doi.org/10.7759/cureus.94399
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Dual Primary Gastric Adenocarcinoma and Diffuse Large B-Cell Lymphoma: A Unique Case With a Cascade of Rare Complications

Peng Lee, Idan Grossmann, Natasha Campbell, Harshavardhan Sanekommu et al.
Cureus
Lymphoma Diagnosis and Treatment
article

Dual Primary Gastric Adenocarcinoma and Diffuse Large B-Cell Lymphoma: A Unique Case With a Cascade of Rare Complications

Peng Lee, Idan Grossmann, Natasha Campbell, Harshavardhan Sanekommu, Shuvendu Sen
article en

Abstract

Concurrent presentation of two primary gastrointestinal cancers is extremely rare. We describe an unusual presentation of a 69-year-old patient without a significant past medical history, who was diagnosed simultaneously with diffuse large B-cell lymphoma and gastric adenocarcinoma. This case is distinguished by the development of severe, rarely reported complications such as duodenocolonic fistula, bowel perforation, pulmonary embolism, and multi-organ failure. The combination of those complications underscores the exceptional complexity of management.

CureusVol. 17(10)
Hackensack Meridian Health (US), Jersey Shore University Medical Center (US)
Openalex Percentile: Top 60%
Lymphoma Diagnosis and Treatment
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Dual Primary Gastric Adenocarcinoma and Diffuse Large B-Cell Lymphoma: A Unique Case With a Cascade of Rare Complications — Peng Lee, Idan Grossmann, et al. · Cureus (2025) | TGRS Research Map | TGRS