Modulation of Mitochondrial Dynamics in Primary Hippocampal Cultures of 5xFAD Mice by Mdivi-1, MFP, and Exogenous Zinc

Mitochondrial fusion and fission significantly influence lipofuscin and amyloid accumulation in 5xFAD cultures, underscoring their potential as therapeutic targets in neurodegenerative diseases. We propose that mitochondrial morphology acts as a key regulator of both cellular homeostasis and disease pathology.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2025-09-26
DOI
https://doi.org/10.31083/fbl44648
Citations
3
Primary Topic
Trace Elements in Health
Type
article
Field-Weighted Citation Impact
3.36
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article

Modulation of Mitochondrial Dynamics in Primary Hippocampal Cultures of 5xFAD Mice by Mdivi-1, MFP, and Exogenous Zinc

A. V. Chaplygina, Daria Zhdanova
3 citations
Frontiers in Bioscience-Landmark
Trace Elements in Health
3.36
article

Modulation of Mitochondrial Dynamics in Primary Hippocampal Cultures of 5xFAD Mice by Mdivi-1, MFP, and Exogenous Zinc

A. V. Chaplygina, Daria Zhdanova
article en
3 citations

Abstract

Mitochondrial fusion and fission significantly influence lipofuscin and amyloid accumulation in 5xFAD cultures, underscoring their potential as therapeutic targets in neurodegenerative diseases. We propose that mitochondrial morphology acts as a key regulator of both cellular homeostasis and disease pathology.

Frontiers in Bioscience-LandmarkVol. 30(9)
Institute of Cell Biophysics (RU)
Openalex Percentile: Top 8%
Trace Elements in Health
3.36
DOIOpen Access PDFOpenAlex
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Modulation of Mitochondrial Dynamics in Primary Hippocampal Cultures of 5xFAD Mice by Mdivi-1, MFP, and Exogenous Zinc — A. V. Chaplygina, Daria Zhdanova · Frontiers in Bioscience-Landmark (2025) | TGRS Research Map | TGRS