PTTG1IP Orchestrates Epithelial–Mesenchymal Transition and DNA Damage Response in Thyroid Cancer Progression
PTTG1IP is a multifunctional node in thyroid cancer, coupling cytoskeletal programs with DDR control, and supporting cell growth and treatment tolerance. The targeting of PTTG1IP, particularly to enhance radiosensitivity, may provide a novel therapeutic strategy for thyroid cancer.
Authors
- Henglu Zhang (ORCID: https://orcid.org/0000-0001-9208-3541)
- Mengyuan Tao (ORCID: https://orcid.org/0009-0006-6799-526X)
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Weiping Lu (ORCID: https://orcid.org/0000-0002-4424-5152)
- Wencheng Zhang (ORCID: https://orcid.org/0000-0003-3730-5361)
- Min Wang (ORCID: https://orcid.org/0000-0003-2651-1231)
- Li Zhou (ORCID: https://orcid.org/0000-0002-6271-6907)
- Jun Ma (ORCID: https://orcid.org/0000-0002-8357-1137)
- Di Yao (ORCID: https://orcid.org/0000-0002-5629-5464)
- Suyu Wang
Institutions
- Xuzhou Medical College (CN)
- Second People’s Hospital of Huai’an (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-09-23
- DOI
- https://doi.org/10.31083/fbl44789
- Primary Topic
- Nutrition, Genetics, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00