Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models
Encoding a key 'hub' scaffolding protein, the 'Disrupted-In-Schizophrenia-1' (<i>DISC1</i>) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. <i>DISC1</i> is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of <i>DISC1</i>-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (<i>Danio rerio</i>) models, to better understand the uniquely complex role of <i>DISC1</i> in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.
Authors
- К. В. Смирнова (ORCID: https://orcid.org/0000-0001-8360-2346)
- Allan V. Kalueff (ORCID: https://orcid.org/0000-0002-7525-1950)
- Longen Yang
- С. В. Чересиз (ORCID: https://orcid.org/0000-0001-8852-2265)
- Andrey D. Volgin
- Lee Wei Lim (ORCID: https://orcid.org/0000-0001-6692-6285)
- N. D. Chizhova
- Tatiana V. Lipina (ORCID: https://orcid.org/0000-0003-1823-465X)
- Murilo S. de Abreu (ORCID: https://orcid.org/0000-0001-5562-0715)
- Tatyana V. Strekalova (ORCID: https://orcid.org/0000-0001-9937-5600)
- Tamara G. Amstislavskaya (ORCID: https://orcid.org/0000-0002-2656-8687)
- Mikhail V. Pletnikov (ORCID: https://orcid.org/0000-0002-8819-6559)
- Adam Stewart
- Alexey V. Doroshkov
- David S Galstya
Institutions
- Southwest University (CN)
- Universidade de Passo Fundo (BR)
- St Petersburg University (RU)
- Sechenov University (RU)
- University of Toronto (CA)
- Novosibirsk State University (RU)
- Azerbaijan Technical University (AZ)
- Federal Almazov North-West Medical Research Centre (RU)
- Western Caspian University (AZ)
- University of Oxford (GB)
- Institute of Physiology and Basic Medicine (RU)
- Institute of Cytology and Genetics (RU)
- Scientific Research Institute of Biochemistry (RU)
- Siberian Branch of the Russian Academy of Sciences (RU)
- Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
- Clinical Research Consortium (US)
- University at Buffalo, State University of New York (US)
- Xi’an Jiaotong-Liverpool University (CN)
- International Society of Nephrology (BE)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-09-25
- DOI
- https://doi.org/10.31083/jin43162
- Citations
- 1
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Saint Petersburg State University