Association of Non‐Coding Repeat Expansions with Parkinson's Disease Risk: Evidence from a <scp>UK</scp> Biobank‐Based Whole‐Genome Sequencing Study
Our large-scale study provides hypothesis-generating evidence. We report a nominal association linking pathogenic C9ORF72 repeats to increased PD risk and, importantly, a novel observation that FMR1 repeats may be protective. © 2025 International Parkinson and Movement Disorder Society.
Authors
- Qingran Yan (ORCID: https://orcid.org/0000-0002-2781-5280)
- Jun Liu (ORCID: https://orcid.org/0000-0001-8300-8646)
- Yu Fan (ORCID: https://orcid.org/0000-0003-4437-1682)
- Jin Wan (ORCID: https://orcid.org/0000-0001-9767-9360)
- Zhen Hu
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-10-11
- DOI
- https://doi.org/10.1002/mds.70081
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00