Qihuang Yishen formula attenuates renal tubular injury by modulating inflammation via the cGAS/STING pathway in diabetic kidney disease
QHYS attenuates renal tubular inflammatory damage via cGAS/STING pathway regulation. This pioneering study provides the first evidence that herbal medicine exerts renal tubule protection through multi-target regulation of innate immune-mediated inflammatory injury in metabolic nephropathy, offering novel scientific evidence for DKD intervention.
Authors
- Yifan Guo (ORCID: https://orcid.org/0000-0003-4872-0456)
- Taiqi Xue
- Tongxia Li (ORCID: https://orcid.org/0000-0001-5787-3193)
- Kaifeng Shi
- Qian Zhang (ORCID: https://orcid.org/0009-0005-5340-5727)
- Xiang-fei Meng (ORCID: https://orcid.org/0000-0002-3135-2071)
- M.S Zhang (ORCID: https://orcid.org/0009-0003-9226-781X)
- Ning Zhang (ORCID: https://orcid.org/0000-0002-8781-4925)
- Pu Yan
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- Xiyuan Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-10-12
- DOI
- https://doi.org/10.1016/j.phymed.2025.157399
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80