Fibroblast and myeloid cells with high mitochondrial RNA content represent biologically significant populations within the OA synovium
These findings suggest high-pMT cells are viable and potentially disease relevant, with their exclusion possibly obscuring key aspects of OA pathophysiology. This highlights the necessity of context-specific QC strategies in OA research and further exploration of high-pMT fibroblast and myeloid populations as potential disease drivers.
Authors
- C. Thomas Appleton (ORCID: https://orcid.org/0000-0001-7148-0767)
- Garth Blackler (ORCID: https://orcid.org/0009-0009-0651-7055)
- Rongkui Luo (ORCID: https://orcid.org/0000-0002-4118-7225)
- Matthew William Grol (ORCID: https://orcid.org/0000-0001-6514-9066)
- Wesley Tran
Institutions
- Western University (CA)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2025-10-12
- DOI
- https://doi.org/10.1016/j.joca.2025.10.002
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Canada Research Chairs
- Canadian Institutes of Health Research
- Schulich School of Medicine and Dentistry