Neonatal cerebral hemodynamics under elevated intracranial pressure: a near-infrared spectroscopy study in piglets
Tissue optical spectroscopy can detect the hemodynamic effects of elevated ICP and could be used to guide interventions aimed at mitigating these effects. Breakpoints identified in hemodynamics highlight a compensatory mechanism, after which ICP changes lead to a larger impact on cerebral hemodynamics. Elevated ICP leads to distinct hemodynamic changes that may precede injury. This study supports the use of tissue optical spectroscopy for non-invasive neonatal neuromonitoring.
Authors
- Rasa Eskandari (ORCID: https://orcid.org/0009-0001-6702-9110)
- Saeed Samaei (ORCID: https://orcid.org/0000-0001-9399-1840)
- Farah Kamar (ORCID: https://orcid.org/0000-0001-5913-0721)
- Mamadou Diop (ORCID: https://orcid.org/0000-0003-1244-7830)
- Sule Karagulleoglu-Kunduraci
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- Robarts Clinical Trials (CA)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-10-11
- DOI
- https://doi.org/10.1038/s41390-025-04446-7
- Primary Topic
- Optical Imaging and Spectroscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Sciences and Engineering Research Council of Canada