Generation of a pseudo-timeline describing progressive human exocrine and endocrine pancreatic pathology in cystic fibrosis through novel semi-quantitative scoring and AI-driven quantitative image analysis

The natural history of pancreatic CF progresses rapidly from duct blockage and dilatation associated with periductal fibrosis to global fat replacement in keeping with early onset of PEI in the majority of affected individuals. Beta cell proportional area is reduced at birth before clinical evidence of pancreatic endocrine dysfunction without significant further loss of islet/beta cell mass with age. Increasing islet disorganisation and intra-islet collagen deposition in older donors temporo-spatially implicates fibrosis in and around the islet as being aetiologically important in the development of CF-related diabetes.

Authors

Institutions

Publication Details

Journal
Diabetologia
Published
2025-10-12
DOI
https://doi.org/10.1007/s00125-025-06559-4
Citations
2
Primary Topic
Cystic Fibrosis Research Advances
Type
article
Field-Weighted Citation Impact
3.04

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Generation of a pseudo-timeline describing progressive human exocrine and endocrine pancreatic pathology in cystic fibrosis through novel semi-quantitative scoring and AI-driven quantitative image analysis

Christine S. Flaxman, Nicole Kattner, Nicola Dyson, Yara Al-Selwi et al.
2 citations
Diabetologia
Cystic Fibrosis Research Advances
3.04
article

Generation of a pseudo-timeline describing progressive human exocrine and endocrine pancreatic pathology in cystic fibrosis through novel semi-quantitative scoring and AI-driven quantitative image analysis

Christine S. Flaxman, Nicole Kattner, Nicola Dyson, Yara Al-Selwi, Dina Tiniakos, Sarah J. Richardson, Rashmi R Maheshwari, Lydia Russell, James Shaw, Minna Honkanen‐Scott, Rowan Coulthard, Günter Klöppel
article en
2 citations

Abstract

The natural history of pancreatic CF progresses rapidly from duct blockage and dilatation associated with periductal fibrosis to global fat replacement in keeping with early onset of PEI in the majority of affected individuals. Beta cell proportional area is reduced at birth before clinical evidence of pancreatic endocrine dysfunction without significant further loss of islet/beta cell mass with age. Increasing islet disorganisation and intra-islet collagen deposition in older donors temporo-spatially implicates fibrosis in and around the islet as being aetiologically important in the development of CF-related diabetes.

DiabetologiaVol. 69(1)
National and Kapodistrian University of Athens (GR), University of Exeter (GB), Royal Victoria Infirmary (GB), Newcastle upon Tyne Hospitals NHS Foundation Trust (GB), Freeman Hospital (GB), Technical University of Munich (DE), Newcastle University (GB)
National Institute for Health and Care Research, Department of Health and Social Care, Cystic Fibrosis Trust, University of Exeter, Newcastle University, Medical Research Council
Openalex Percentile: Top 8%
Cystic Fibrosis Research Advances
3.04
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.