Markers of Tissue Hypoperfusion and Response to Vasopressors in Patients with Septic Shock

Background Patients in the early stage of septic shock require individualized fluid resuscitation and early administration of vasopressors to ensure tissue perfusion. We aimed to assess the performance of tissue perfusion markers in patients with septic shock and assessing its role in predicting the response to vasopressors. Methods This observational study was included 90 patients with septic shock within the first 24 hours of admission to the intensive care. Arterial (a) and central venous (cv) blood samples were obtained before beginning vasopressors (T0), and then at 12 and 24 hours after the initial sampling (T12, 24) for analysis of oxygen (O2), carbon dioxide (CO2) and other laboratory measures. Results In our cohort; 51 (56.7%) resolved and 39 (43.3%) deceased. The PaO2, PaCO2 and SaO2 showed significantly lower values in the deceased than resolved patients after 24 hours (P