Single-Cell Transcriptome Profiling Reveals the Immune Dysregulation Characteristics of Mice Infected With <i>Brucella abortus</i>
scRNA-seq revealed that Brucella infection significantly alters the immune microenvironment in mice, providing insight into a better understanding of brucellosis pathogenesis and the immune evasion strategies of this sophisticated pathogen.
Authors
- Guangzhi Zhang (ORCID: https://orcid.org/0000-0003-4968-5322)
- Hyeongheon Cha (ORCID: https://orcid.org/0000-0001-9215-8072)
- Jianxin Ye (ORCID: https://orcid.org/0000-0002-6118-8583)
- Xiaofeng Xu (ORCID: https://orcid.org/0000-0002-3998-9245)
- Lang Lv
- Pascal Boireau (ORCID: https://orcid.org/0000-0002-3998-7792)
- Yu Feng (ORCID: https://orcid.org/0000-0003-0034-6397)
- Xuezheng Fan (ORCID: https://orcid.org/0000-0001-8598-2872)
- Jiabo Ding
- Chenguang Shen (ORCID: https://orcid.org/0000-0001-8607-3750)
- Yan Li (ORCID: https://orcid.org/0000-0003-0607-3166)
- Yinghui Zhang (ORCID: https://orcid.org/0000-0002-4588-7819)
- Xiaowei Peng (ORCID: https://orcid.org/0009-0003-0003-6572)
- Hui Jiang (ORCID: https://orcid.org/0000-0003-4588-7074)
- Qingchun Shen
Institutions
- École Nationale Vétérinaire d'Alfort (FR)
- Département Santé Animale (FR)
- Zhujiang Hospital (CN)
- China Institute of Veterinary Drug Control (CN)
- Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (FR)
- Chinese Academy of Agricultural Sciences (CN)
- Institute of Animal Sciences (CN)
- Innovation Team (China) (HK)
- China Agricultural University (CN)
- Southern Medical University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1093/infdis/jiaf522
- Citations
- 2
- Primary Topic
- Brucella: diagnosis, epidemiology, treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.71