Indirubin regulates M1/M2 polarization and inhibits ferroptosis in dextran sulfate sodium induced colitis and in cultured THP-1 cells
IDR skews the polarization of macrophages from M1 to M2. Furthermore, it inhibits ferroptosis in both mice and THP-1-derived macrophages. These mechanisms may contribute to the therapeutic effects of IDR in the treatment of UC.
Authors
- Haipeng Zhu (ORCID: https://orcid.org/0000-0002-9269-0074)
- Song Chen (ORCID: https://orcid.org/0000-0003-2521-717X)
- Jin‐Ru Zhang
- Yan Luo (ORCID: https://orcid.org/0000-0001-8156-6572)
- Shin‐Huei Fu (ORCID: https://orcid.org/0000-0001-9697-6814)
- Bin Wen (ORCID: https://orcid.org/0000-0003-3449-5841)
- Zhe Liu (ORCID: https://orcid.org/0000-0002-0168-6572)
- Yingjie Hu (ORCID: https://orcid.org/0000-0002-5260-4151)
- Yongxiang Huang (ORCID: https://orcid.org/0000-0003-1188-4852)
- Qingyang Zhong
- Huijun Zhong
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Dongguan People’s Hospital (CN)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2025-10-11
- DOI
- https://doi.org/10.1080/13880209.2025.2568215
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00