Basophils in Skin‐Mediated Sensitization Drive Subsequent Lung Inflammation in Airway‐Challenged Mice
We find that basophils promote IgE formation and lung sensitization to skin-encountered allergens and drive secondary allergen-induced lung inflammation. We separate the role of basophils in sensitization from their effector function during anaphylaxis or lung inflammation relevant to envision novel strategies to prevent the development of allergic comorbidities.
Authors
- Daniel Radtke (ORCID: https://orcid.org/0000-0003-3241-4542)
- David Voehringer (ORCID: https://orcid.org/0000-0001-6650-0639)
- Eugene Choi
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Immunomedics (Germany) (DE)
Publication Details
- Journal
- Allergy
- Published
- 2025-10-11
- DOI
- https://doi.org/10.1111/all.70093
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Deutsche Forschungsgemeinschaft
- Universitätsklinikum Erlangen