Expression of mutant <scp>TIE2</scp> p.<scp>L914F</scp> during mouse development causes embryonic lethality and defects in vascular remodeling
The TIE2<sup>L914F</sup> mice used in this study represent a novel genetic model of TIE2 p.L914F-driven vascular disease. This study provides the first experimental evidence that this mutation is incompatible with early prenatal development due to its deleterious effects on the vasculature, illustrating the vital role of balanced TIE2 signaling during vessel development and remodeling.
Authors
- Sandra Schrenk
- Kara M. Soroko
- Chhiring Sherpa
- Elisa Boscolo (ORCID: https://orcid.org/0000-0002-6996-0419)
- Damien Reynaud (ORCID: https://orcid.org/0000-0001-8765-8419)
- Lindsay J. Bischoff
- Ashok Arasu (ORCID: https://orcid.org/0000-0002-5827-2290)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Developmental Dynamics
- Published
- 2025-10-11
- DOI
- https://doi.org/10.1002/dvdy.70087
- Citations
- 2
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 4.01