Case report: recurrent chest pain as initial manifestation of rapidly progressing light-chain cardiac amyloidosis with microvascular infiltration—a novel red flag associated with poor outcomes
This case underscores chest pain as a critical clinical marker, potentially indicating microvascular amyloid infiltration in patients with light-chain cardiac amyloidosis, particularly those with unobstructed coronary arteries. Its assessment may also have implications for future therapies.
Authors
- Gianfranco Sinagra (ORCID: https://orcid.org/0000-0003-2700-8478)
- Rossana Bussani (ORCID: https://orcid.org/0000-0001-8241-9726)
- Aldostefano Porcari (ORCID: https://orcid.org/0000-0003-3307-0825)
- Marco Merlo
- Carla Indennidate (ORCID: https://orcid.org/0009-0006-0012-5542)
Institutions
- University of Trieste (IT)
- The Royal Free Hospital (GB)
- Amyloidosis Foundation (US)
- ERN GUARD-Heart (NL)
- European Hospital (IT)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- University College London (GB)
Publication Details
- Journal
- European Heart Journal - Case Reports
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1093/ehjcr/ytaf521
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00