Prognostic value of visually and computationally assessed tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer (TBCRC-030)
Visual examination TILs and computational assessment CmbI were each associated with response to neoadjuvant chemotherapy in triple-negative breast cancer in the overall cohort and the paclitaxel arm. Computational assessment CmbI did not outperform visual assessment. Further validation is needed before clinical implementation of computational approaches.
Authors
- Stuart J. Schnitt (ORCID: https://orcid.org/0000-0002-3608-7828)
- Tiffany A. Traina (ORCID: https://orcid.org/0000-0003-3597-0050)
- Satabhisa Mukhopadhyay
- Jennifer M. Specht (ORCID: https://orcid.org/0000-0003-1484-2113)
- Ian E. Krop (ORCID: https://orcid.org/0000-0002-6380-5944)
- Xiangying Chu (ORCID: https://orcid.org/0009-0000-3474-3804)
- Guilherme Nader Marta (ORCID: https://orcid.org/0000-0001-7864-3637)
- Erica Stringer-Reasor (ORCID: https://orcid.org/0000-0002-1862-3367)
- Adam Brufsky (ORCID: https://orcid.org/0000-0001-8080-7960)
- Susan Dent (ORCID: https://orcid.org/0000-0002-9183-9340)
- Nadine Tung (ORCID: https://orcid.org/0000-0003-1422-3734)
- Lisa A. Carey (ORCID: https://orcid.org/0000-0003-2388-4649)
- Nabihah Tayob (ORCID: https://orcid.org/0000-0001-6088-167X)
- Kathy D. Miller (ORCID: https://orcid.org/0000-0002-7125-883X)
- Busem Binboğa Kurt (ORCID: https://orcid.org/0000-0002-7161-1496)
- Mothaffar F. Rimawi (ORCID: https://orcid.org/0000-0002-4284-5656)
- Erica L. Mayer (ORCID: https://orcid.org/0000-0001-5430-8957)
- Vandana G. Abramson (ORCID: https://orcid.org/0000-0002-6855-1322)
- Tathagata Dasgupta
- Cesar Augusto Santa-Maria
- Michelle K. DeMeo
Institutions
- University of North Carolina at Chapel Hill (US)
- Indiana University Health (US)
- Brigham and Women's Hospital (US)
- Program for Appropriate Technology in Health (US)
- Beth Israel Deaconess Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- University of Washington (US)
- Critical Path Institute (US)
- Yale Cancer Center (US)
- University of Alabama at Birmingham (US)
- Clinical Research Institute (US)
- Indiana Cancer Consortium (US)
- Dana-Farber Cancer Institute (US)
- Duke Institute for Health Innovation (US)
- Duke Medical Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- O'Neal Comprehensive Cancer Center
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1093/jnci/djaf289
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00