Social relationships and epigenetic markers of aging in middle-aged and older adults: cross-sectional and prospective analyses
In middle-aged and older Australians, positive components of social relationships showed weak associations with lower epigenetic age. Social isolation and living alone were associated with older epigenetic age only in men. Our study suggests that the benefits of social relationships to health are partially captured by epigenetic markers of aging.
Authors
- Pierre‐Antoine Dugué (ORCID: https://orcid.org/0000-0003-2736-3023)
- Graham G. Giles (ORCID: https://orcid.org/0000-0003-4946-9099)
- Roger Laughlin Milne (ORCID: https://orcid.org/0000-0001-5764-7268)
- Danmeng Lily Li (ORCID: https://orcid.org/0009-0006-7799-819X)
- Allison M. Hodge (ORCID: https://orcid.org/0000-0001-5464-2197)
- Melissa C. Southey (ORCID: https://orcid.org/0000-0002-6313-9005)
- Xiaojing Xu (ORCID: https://orcid.org/0000-0003-0469-0224)
Institutions
- The University of Melbourne (AU)
- Cancer Council Victoria (AU)
- Monash Health (AU)
- Monash University (AU)
Publication Details
- Journal
- The Journals of Gerontology Series B
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1093/geronb/gbaf194
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00