Thiofunctionalization of Silyl Enol Ether: An Efficient Approach for the Synthesis of β-Keto Sulfides

<i>β</i>-Keto sulfides are a class of compounds containing both carbonyl (C=O) and thioether (C-S-C) functionalities, exhibiting significant potential in the field of medicinal chemistry. This study employs the silyl enol ether as the substrate, enabling the formation of C-S bonds under catalyst- and additive-free conditions, thereby facilitating the efficient synthesis of <i>β</i>-keto sulfides. The reaction proceeds rapidly and efficiently, exhibiting a broad substrate scope, and a total of 31 target compounds were synthesized with up to 95% yields.