Acute and chronic nasal inflammation induces lymphangiogenesis in the olfactory mucosa in mice
Nasal inflammation induces region-specific lymphangiogenesis during the acute phase, likely driven by local proliferation of lymphatic endothelial cells. Under chronic inflammatory conditions, both inflammation and lymphangiogenesis expand across the olfactory mucosa. Further studies are needed to elucidate the underlying molecular mechanisms and to determine the functional relevance of olfactory lymphangiogenesis.
Authors
- Atsuyoshi Shimada (ORCID: https://orcid.org/0000-0002-1347-7022)
- Aki Obara
- Sanae Hasegawa‐Ishii (ORCID: https://orcid.org/0000-0001-7396-9187)
- Yukihiko Sugimoto (ORCID: https://orcid.org/0000-0001-6973-932X)
- Fumiaki Imamura
- Robert Dantzer
- Geoffroy Laumet (ORCID: https://orcid.org/0000-0001-6752-3592)
- Rei Settsu
- Suzuho Komaki
- Ryuichi Imai
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Kyorin University (JP)
- Penn State Milton S. Hershey Medical Center (US)
- Michigan State University (US)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-10-07
- DOI
- https://doi.org/10.1016/j.bbih.2025.101119
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00