STRUCTURAL AND ANTIBACTERIAL STUDIES OF THE CONSTITUENTS OF THE ESSENTIAL OIL OF CLEISTOPHOLIS PATENS ENGL. AND DIELS COLLECTED IN GAGNOA (COTE DIVOIRE)

The essential oil of Cleistopholis patens (Annonaceae) leaves was obtained by hydrodistillation using a traditional still from leaves collected in the Gagnoa department, Cote dIvoire, with a yield of 0.21%. Chemical analyses were carried out by gas chromatography-mass spectrometry (CPG-MS) and carbon-13 nuclear magnetic resonance (13CNMR). Sixteen compounds, accounting for 95.75% of the total composition, were identified. The chemical profile is characterized by a balanced distribution between hydrocarbon monoterpenes (34.88%) and hydrocarbon sesquiterpenes (36.84%), complemented by oxygenated sesquiterpenes (21.18%) and an aromatic hydrocarbon, naphthalene (5.13%). The major constituents were p-cymene (14.36%), caryophyllene (10.77%), and 3-carene (9.23%). The essential oil of Cleistopholis patens from Gagnoa exhibited pronounced bactericidal activity, attributed to its chemical diversity, notably the presence of compounds well recognized for their effectiveness against a variety of microbial agents.