SALIVARY BIOMARKERS IN PROSTHODONTICS: A COMPREHENSIVE LITERATURE REVIEW

Saliva,often termed the mirror of the body, is increasingly recognized for its diagnostic potential in oral and systemic diseases. With advancements in proteomics, genomics, and metabolomics, salivary biomarkers offer a non-invasive, cost-effective, and patient-friendly means to support diagnosis, prognosis, and monitoring across many dental disciplines. Prosthodontics particularly benefits from this because prosthetic rehabilitation impacts and is impacted by systemic health, mucosal status, and oral micro environment. This review examines the biochemical basis of salivary diagnostics,categories of relevant biomarkers,and their specific applications in prosthodontic care covering edentulism,ridge resorption,implant health, xerostomia, oral cancer surveillance,and prosthesis related complications.Technological advances, limitations, and future directions for integrating chairside salivary diagnostics into personalized prosthodontics are also discussedThe evidence underscores salivary biomarkers promise in enhancing patient-centered outcomes and shaping the future of biomarker-guided prosthetic therapy.