Single-cell Analyses Highlight the Proinflammatory Contribution of Low-density Neutrophils in the Acute Phase of Severe Fever With Thrombocytopenia Syndrome
This study revealed an increased proportion and heightened pro-inflammatory activity of LDNs during the acute phase of SFTS, closely correlating with disease severity. These findings suggest that LDNs may serve as potential early-warning biomarkers for predicting severe progression in patients with SFTS.
Authors
- Yan Dai (ORCID: https://orcid.org/0009-0000-6463-7201)
- Zhan Yang (ORCID: https://orcid.org/0000-0001-8082-7793)
- Ke Jin (ORCID: https://orcid.org/0000-0002-4310-8172)
- Chuanlong Zhu (ORCID: https://orcid.org/0000-0001-6557-1654)
- Yinghua Mao
- Tingting Zhou (ORCID: https://orcid.org/0000-0001-9278-1470)
- Nannan Hu (ORCID: https://orcid.org/0009-0009-3872-3849)
- Y. Zhang (ORCID: https://orcid.org/0009-0006-3951-8773)
- Jun Li (ORCID: https://orcid.org/0009-0005-1830-2327)
- Ping Shi (ORCID: https://orcid.org/0000-0002-7950-031X)
- Yuan Liu (ORCID: https://orcid.org/0000-0001-9452-0442)
- Tao Yang (ORCID: https://orcid.org/0000-0002-1127-9364)
- Jin Zhu (ORCID: https://orcid.org/0000-0001-8745-4555)
- Chunhui Wang (ORCID: https://orcid.org/0009-0001-6367-9941)
- Xuewei Sun
- Jiaying Zhao (ORCID: https://orcid.org/0009-0009-6741-1764)
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-09-29
- DOI
- https://doi.org/10.31083/fbl40723
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 0.00