Integrated Analysis of Single-cell and Bulk-RNA Sequencing Data to Identify Redox-related Genes as Prognostic Biomarkers and Therapeutic Targets of Lung Adenocarcinoma With Osimertinib Resistance
Targeting CAFs represents a promising strategy to overcome osimertinib resistance. Our six-gene redox signature offers a clinical framework for patient risk stratification and novel therapeutic strategy design. Future work will explore these targets to develop new treatments for LUAD.
Authors
- Daya Luo (ORCID: https://orcid.org/0000-0003-1227-2436)
- Chaoxing Liu (ORCID: https://orcid.org/0009-0006-8015-6612)
- Rong Qi (ORCID: https://orcid.org/0000-0002-0627-9968)
- Chao Shi (ORCID: https://orcid.org/0000-0002-2205-6457)
- Jiabin Ding
- Guohua Zhang
- Feng Qiu
- Fang Chen (ORCID: https://orcid.org/0000-0003-4196-9734)
- Ting Luo (ORCID: https://orcid.org/0009-0005-2271-8202)
- Feng Yu
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-09-25
- DOI
- https://doi.org/10.31083/fbl40454
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province