Notch1 Inhibition Exacerbates APAP-Induced Liver Injury via β-Catenin and Macrophage Polarization
Notch1 inhibition unexpectedly worsens AILI by amplifying macrophage-driven pro-inflammatory responses via β-catenin signaling. These findings highlight the Notch1-β-catenin axis as a key regulator of hepatic macrophage function and a potential therapeutic target for sterile liver inflammation.
Authors
- Yi-Xuan Shao (ORCID: https://orcid.org/0009-0005-6853-170X)
- Jiaying Zhao (ORCID: https://orcid.org/0009-0009-6741-1764)
- Jingjing Dai
- Jun Li (ORCID: https://orcid.org/0000-0002-5190-0733)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-9647-8847)
- Tao Yang (ORCID: https://orcid.org/0000-0002-1127-9364)
- Longfeng Jiang (ORCID: https://orcid.org/0000-0001-8058-6838)
- Ping Shi (ORCID: https://orcid.org/0000-0002-7950-031X)
- Jiangang Zhou
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-09-25
- DOI
- https://doi.org/10.31083/fbl43853
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China