PTDSS1 Drives Glycolysis and Malignant Progression of Lung Cancer Through Maintaining Nuclear–Mitochondrial Homeostatic Crosstalk
PTDSS1 functions as a multifunctional oncogene. It drives lung cancer progression through PKM2-mediated nuclear-mitochondrial homeostatic crosstalk. PTDSS1 represents a potential prognostic biomarker and therapeutic target.
Authors
- Yu‐Ying He (ORCID: https://orcid.org/0000-0002-2665-7962)
- Hailun Wang (ORCID: https://orcid.org/0000-0001-8651-2856)
- Xingxiang Pu (ORCID: https://orcid.org/0000-0002-2743-7080)
- Qiao Wang (ORCID: https://orcid.org/0000-0003-0544-5108)
- Yusheng Li (ORCID: https://orcid.org/0000-0001-5786-3016)
Institutions
- The First People's Hospital of Shunde (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- First People’s Hospital of Zunyi (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-09-26
- DOI
- https://doi.org/10.31083/fbl45020
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94