Fto-Mediated m6A Demethylation of Anxa1 Attenuates Cardiac Ischemia–Reperfusion Injury With Suppression of Nlrp3 Inflammasome Signals
Fto enhances <i>Anxa1</i> and mitigates myocardial I/R injury with suppression of nucleotide-binding oligomerization domain-, leucine-rich repeat-, and pyrin domain- containing receptor 3 (<i>Nlrp3</i>)-inflammasome signaling <i>in vivo</i>, identifying the Fto-<i>Anxa1</i> axis as a mechanistic contributor and potential therapeutic target.
Authors
- Lijia Xu
- Hao Zhang (ORCID: https://orcid.org/0009-0008-1266-8426)
- Chao‐Jie He (ORCID: https://orcid.org/0000-0001-6183-6571)
- Huilin Hu (ORCID: https://orcid.org/0000-0003-1619-4682)
- Haojie Yang
Institutions
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-09-28
- DOI
- https://doi.org/10.31083/fbl42765
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province